New Sidewinder DNA synthesis method enables rapid, accurate construction of AI-predicted genomes
By
Elie Dolgin
Summary
A new DNA synthesis method called Sidewinder enables fast, affordable, and highly accurate construction of genetic sequences, addressing a bottleneck where AI models can predict novel genomes faster than scientists can physically build them. Sidewinder assembles dozens of sequences simultaneously in a single test tube with exceptional precision—just one error per 10 million assembly events—far outperforming conventional methods that misfire every 10 to 30 joins. This breakthrough makes it practical to physically realize the DNA sequences that generative AI models are now producing.
Source
Hacker NewsNew Sidewinder DNA synthesis method enables rapid, accurate construction of AI-predicted genomesspectrum.ieee.orgKey quotes
· 3 pulledA new method for writing DNA promises to unlock the potential of generative AI in biology, giving scientists a fast, affordable, and accurate way to physically build the novel genetic sequences that predictive models are now producing faster than anyone can construct them.
The technique, called Sidewinder, can assemble dozens of genetic sequences simultaneously in a single test tube, producing just one incorrect junction for every 10 million assembly events—a level of precision that far surpasses conventional methods, which misfire roughly once every 10 to 30 joins.
Sidewinder also draws on che
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