N 4 -Acetylcytidine enhances synthetic mRNA translation yield and fidelity
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Shalini Oberdoerffer
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Nature CommunicationsN 4 -Acetylcytidine enhances synthetic mRNA translation yield and fidelitynature.comNature, Published online: 01 July 2026; doi:10.1038/s41586-026-10729-8 Different RNA modifications elicit different translation elongation rates for in vitro transcribed mRNAs that result in disparate translation outputs and fidelity, as shown here for N4-acetylcytidine versus the industry standard for synthetic mRNAs, N1-methylpseudouridine.
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