Designing small molecules targeting a cryptic RNA binding site through base displacement

Qt45: A small polymerase ribozyme that can synthesize itself

AI-Driven Protein Binder Design: Progress and Pitfalls in Evaluation Practices

This article discusses the rapid advancement of de novo protein binder design using AI, including antibodies and nanobodies. While the field

Nature research paper: Zero-shot design of drug-binding proteins via neural iterative selection−expansion

Nature research paper: Zero-shot design of drug-binding proteins via neural iterative selection−expansion

Congratulations to the Michelle Chang Lab, publishing “Targeted enzyme discovery using metal-coordination mining” today in @Nature. Great work from Yanni and Michelle. Full paper

Congratulations to the Michelle Chang Lab, publishing “Targeted enzyme discovery using metal-coordination mining” today in @Nature. Great work from Yanni and Michelle. Full paper

Derek Lowe on "Peptides"

Zero-shot design of drug-binding proteins via neural iterative selection−expansion