Identification of a mechanism-based binding mode for a histone deacetylase 6 inhibitor
4h ago· 1 min readNews
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bskyIdentification of a mechanism-based binding mode for a histone deacetylase 6 inhibitordoi.orgBreaking: BAS-2, a new HDAC6 inhibitor without typical zinc-binding group was identified! Using X-ray, mutagenesis, SARs & modeling, its unique mechanism is unraveled! PMID:42248829, Nat Commun 2026, @NatureComms #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
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