Large-scale Hi-C analysis of 1,025 species reveals distinct evolutionary paths in genome architecture
By
Kai Ye (叶凯)1,2,7,8,9,10 Send email to [email protected]
Summary
A large-scale comparative analysis of Hi-C data from 1,025 species reveals the evolutionary trajectories of genome architecture. The study identifies two higher-order spatial organizations: "global folding" (karyotype spatial organization) and "checkerboard" (chromatin compartment spatial organization). Early unicellular life forms showed random genome configurations. Plants predominantly evolved toward global folding architecture, while animals progressively developed checkerboard compartmentalization. Despite these distinct evolutionary paths, both strategies converge on spatial organization as a conserved mechanism for gene regulation.
Source
bskyLarge-scale Hi-C analysis of 1,025 species reveals distinct evolutionary paths in genome architecturecell.comKey quotes
· 4 pulledSpatial genome organization plays a crucial regulatory role, but its evolutionary development remains unclear.
Earlier unicellular life forms mostly displayed random genome configurations.
Throughout the evolution of plants, global folding became and remained the prominent architecture.
Both converge on spatial organization as a conserved strategy for gene regulation.
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