Two complementary gut-brain pathways drive protein-specific appetite in response to amino acid deficiency
By
Greg S. B. Suh
Summary
This article investigates the biological mechanisms behind protein-specific appetite when dietary essential amino acids (EAAs) are deficient. Using Drosophila as a model organism, the researchers identify that the peptide CNMamide (CNMa) drives EAA hunger through two complementary pathways: a fast gut-brain neuronal pathway where gut neurons bearing CNMa receptors signal the brain to suppress sugar-sensing neurons, and a slower systemic signal. The work reveals a coordinated neuronal and hormonal response system that drives animals to seek protein-rich food when EAA levels are low.
Source
bskyTwo complementary gut-brain pathways drive protein-specific appetite in response to amino acid deficiencydoi.orgKey quotes
· 5 pulledA lack of sufficient dietary proteins leads to nutrient-specific appetite for essential amino acid (EAA)- or protein-rich food.
The first is a fast pathway triggered by neurons in the gut bearing a CNMa receptor, which in turn signals the brain to suppress the activity of sugar-sensing neurons.
Second, a slower signal is induced...
A deficit in dietary protein elicits a nutrient-specific appetite, yet the underlying mechanisms remain poorly understood.
In this work, we identify coordinated neuronal and systemic mechanisms in ...
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