How cells keep genomic hitchhikers under control

Much of the genome is made up of repetitive DNA sequences that trace back to ancient mobile elements, many of which have lost their ability to copy themselves into new locations but can still cause problems if they become active again at the wrong time. Now, two studies published in Molecular Cell from FMI scientists reveal how cells keep these potentially disruptive genetic elements under control. The researchers found that a protein complex called ChAHP acts as a targeted genome-defense system, preventing the transcription machinery from switching on these elements in mouse cells. The findings offer insight into how cells manage repetitive sequences while protecting genome stability.

How cells keep genomic hitchhikers under control

Source

You might also wanna read

Recognition and silencing of a new transposable element

Nature research paper: Replication-stress-induced chromatin loops protect fork stability

Telomere biology and telomerase regulation across species: evolutionary insights into aging, longevity, and genome stability

Extrachromosomal DNA drives cancer hallmarks through genomic chaos and accelerated evolution

Study reveals nanotube-based intercellular DNA transfer driven by genome instability in human cells

Scientists Engineer Proteins to Act as Qubits for Cellular Disease Monitoring

Comments