Gut microbiome composition predicts melanoma recurrence risk in patients on immunotherapy, large trial finds
By
Jiyoung Ahn1,2,9 Send email to [email protected]
Summary
This study analyzed stool samples from 674 patients with resected high-risk melanoma enrolled in the phase 3 CheckMate 915 clinical trial to evaluate whether pre-treatment gut microbiome features predict recurrence-free survival during adjuvant immune checkpoint blockade (ICB) therapy. The research found that the gut microbiome differs by geographic region but remains stable during ICB treatment, and region-specific bacterial markers can predict relapse. The study addresses the clinical challenge that 25%–40% of patients experience recurrence despite adjuvant ICB, and aims to identify microbiome-based biomarkers to improve treatment personalization.
Source
bskyGut microbiome composition predicts melanoma recurrence risk in patients on immunotherapy, large trial findscell.comKey quotes
· 3 pulledPatients with resected, high-risk melanoma receive adjuvant immune checkpoint blockade (ICB), yet clinical benefit remains unpredictable, with 25%–40% of patients experiencing recurrence.
Region-specific and cross-region meta-analyses identified pre-treatment taxa associated with recurrence-free survival.
In 674 high-risk melanoma patients across five regions, the gut microbiome differs by region but remains stable during ICB treatment, and region-specific bacterial markers predict relapse.
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