Systematic review of metastatic Crohn's disease: clinical features, demographics, and treatment approaches
Summary
This systematic review examines metastatic Crohn's disease (MCD), a rare cutaneous manifestation of Crohn's disease. Analyzing 230 studies covering 610 patients (161 males, 449 females), the review finds that genital erythema and oedema are hallmark features, with women and younger patients more commonly affected. Notably, MCD predated luminal Crohn's diagnosis in one-third of cases. Treatments ranged from topical and systemic therapies to surgical modalities, with anti-TNF therapy being the most reported. The authors highlight the need for standardized reporting, treatment guidelines, and prospective trials.
Source
bskySystematic review of metastatic Crohn's disease: clinical features, demographics, and treatment approachesfg.bmj.comKey quotes
· 5 pulledOne-third of patients with MCD did not have a diagnosis of luminal or perianal CD.
MCD was predominantly diagnosed in younger women and affected the genitalia, progressing to involve other sites such as the perineum and groin.
Ulceration is a feature of aggressive disease involving multiple sites.
There is a clear need for standardised reporting, treatment guidelines and prospective interventional trials to enable evidence-based recommendations.
Genital erythema and oedema were hallmark clinical features.
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