Lineage tracing methods review: Genetic markers, synthetic barcodes, and natural variants for cell fate mapping
This review article synthesizes three major approaches to lineage tracing—genetic markers, synthetic barcodes, and natural variants—and their integration with single-cell multi-omics and spatial profiling technologies. It discusses how cell fate mapping is essential for understanding development, tissue homeostasis, regeneration, and disease mechanisms. The article also addresses computational challenges in analyzing lineage tracing data and provides experimental design guidance for researchers aiming to decode cell fate decisions in both health and disease contexts.
Key quotes
Cell fate dictates the developmental trajectory a cell follows—from its origin to its terminal identity—under physiological and pathological conditions.
Mapping these fates is essential for understanding tissue development, homeostasis, and repair, as well as how aberrant lineage decisions drive disease.
Cell fate choice is often conceptualized using Waddington's landscape, where a cell rolls down a branched, contoured hill, progressively restricting its developmental potential until it settles in...
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