Enhanced B cell priming induces broadly neutralizing HIV-1 apex antibodies

Challenges and approaches in developing an HIV vaccine through broadly neutralizing antibodies

This article discusses the challenges and potential approaches to developing an effective HIV vaccine. It highlights that while therapies ex

Efficient mRNA delivery to resting T cells to reverse HIV latency

Phase 1 trial finds triple monoclonal antibody combination safe and effective for HIV-1 prevention

This phase 1, multicentre, randomised, open-label trial (HVTN 140/HPTN 101 part B) evaluated the safety, pharmacokinetics, and neutralisatio

Engineered antibodies enhance complement-mediated immune clearance against drug-resistant bacterial infections

Researchers engineered monoclonal antibodies (mAbs) that bypass the initial steps of the classical complement activation pathway, enhancing

Programming the immunological properties of mRNA vaccines for cancer

Genome-wide CRISPR screens identify host factors that promote and restrict HIV infection in primary CD4+ T cells

This article describes a systematic genome-wide CRISPR activation (CRISPRa) and CRISPR knockout screening approach in primary human CD4+ T c