Chaperone-Assisted Protein Folding: Hartl and Horwich Win 2011 Lasker Award for Molecular Machinery Discovery

Analyzing Redundancy in Natural Protein Fold Space and the Role of Generative AI in Biomolecular Modeling

This research note from Ligo explores the concept of redundancy in natural protein fold space, examining how deep neural networks and genera

Understanding Protein Complexity: The Biological Challenge That AI Like AlphaFold Solved

This article explores the fundamental complexity of proteins in biology, explaining how their proper folding is essential for life and how m

Discovery of Dendritic Nanotubular Networks Enables New Form of Brain Cell Communication

Researchers have discovered a previously unknown form of intercellular communication in the brain through dendritic nanotubular networks. Us

Shortened TDP-43 isoforms form steric zippers driving aggregation and mislocalization in ALS pathology

This scientific research article investigates shortened TDP-43 (sTDP-43) splice isoforms and their role in neurodegenerative disorders like

Computational Design of Peptide Masks Enables Conditionally Active Miniprotein Therapeutics

This article presents a novel computational approach for designing conditionally active miniprotein binders through de novo peptide masks. T

Nature research paper: Alternate RNA decoding results in stable and abundant proteins in mammals