AAV-mediated FGF21 gene therapy extends health span and lifespan in aged mice through multi-tissue adaptations
By
Fatima Bosch1,2,3 Send email to [email protected]
Summary
This study demonstrates that a one-time muscle-directed AAV-mediated FGF21 gene therapy in aged and geriatric mice extends health span and lifespan. The treatment normalized body weight and adiposity, improved insulin sensitivity and glucose homeostasis, and induced whole-body tissue-specific adaptations including enhanced metabolic and mitochondrial function, restored proteostasis, and reduced inflammation, fibrosis, and amyloidosis. The therapy prevented multi-organ age-related pathology and maintained systemic cell fitness, offering a potential gerotherapeutic approach for extending health span.
Source
Twitter / XAAV-mediated FGF21 gene therapy extends health span and lifespan in aged mice through multi-tissue adaptationscell.comKey quotes
· 3 pulledHere, we demonstrated that aged and geriatric male and female mice treated with muscle-directed adeno-associated viral (AAV) vector-mediated fibroblast growth factor 21 (FGF21) gene therapy extended health span and lifespan with sustained organ benefits.
This treatment normalized body weight and adiposity, improved insulin sensitivity and glucose homeostasis.
Bosch and colleagues described that one-time AAV-FGF21 gene therapy in aged mice induced whole-body tissue-specific adaptations, including improved metabolic and mitochondrial function, restored proteostasis, and reduced adiposity, inflammation, fibrosis, and amyloidosis.
You might also wanna read
Time-restricted feeding extends healthspan in both sexes and lifespan in male C57BL/6 J mice - Nature Aging
Long-term comparative analysis of AAV9-mediated gene replacement therapies for spinal muscular atrophy in mice
First human treated in gene therapy trial aiming to reverse cellular aging through partial reprogramming
A landmark clinical trial has begun treating the first human participant with a gene therapy that aims to reverse cellular aging. The approa
scientificamerican.com·17d agoSIRT6 overexpression counteracts chromatin aging in the male murine liver
Mouse Study Links Protein TTP to Improved Strength and Reduced Frailty in Aging
Researchers at the University at Buffalo identified the protein tristetraprolin (TTP) as a potential target for reducing age-related frailty
sciencealert.com·23d ago
UCSD gene therapy preserves brain function by boosting protective protein rather than removing toxic TDP-43
UC San Diego scientists have developed an experimental gene therapy called SynCav1 that takes a novel approach to fighting the toxic protein
flip.it·24d ago
Comments
Sign in to join the conversation.
No comments yet. Be the first.