JCI review maps biological age tools from epigenetic clocks to AI, calls for stronger evidence before clinical use
By
Pooja Toshniwal Paharia
Summary
A major JCI review maps the evolution of biological age (BA) measurement tools — from functional tests and blood biomarkers to epigenetic clocks (e.g., Horvath, Hannum, PhenoAge, GrimAge), proteomics, imaging, wearables, and AI-based systems. These tools can predict health risks and mortality better than chronological age alone, but the field lacks standardization, interpretability, and prospective validation before these tools can be used routinely in patient care.
Source
Twitter / XJCI review maps biological age tools from epigenetic clocks to AI, calls for stronger evidence before clinical usenews-medical.netKey quotes
· 3 pulledThe distinction between CA and BA and the progression of epigenetic clocks through multiple generations.
First-generation clocks (e.g., Horvath, Hannum) were trained to predict chronological age.
Second-generation clocks (e.g., PhenoAge, GrimAge) ...
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