A hidden weakness in deadly cancers could lead to powerful new treatments

Protein-based pan-RAS inhibitor induces tumor regression in female mice via IFNγ and CD8+ T cell-dependent tumor necrosis

Study reveals resistance mechanisms and potential treatment strategy for anaplastic thyroid cancer using type II RAF inhibitors

This study investigates resistance mechanisms to MAPK inhibition in anaplastic thyroid cancer (ATC), a highly lethal cancer. Using multi-reg

Targeting genomic instability: From chemotherapy to precision medicine in cancer treatment

This article examines genomic instability as a hallmark of cancer, explaining how it drives malignant transformation through accumulated gen

Combination therapy with RAS inhibitors shows promise for pancreatic cancer regression and resistance prevention

This research article presents a study on a targeted combination therapy for pancreatic ductal adenocarcinoma (PDAC), one of the deadliest c

Hallmarks of Cancer: A 25-Year Retrospective and Future Directions in Tumor Biology

This review by Douglas Hanahan revisits the "hallmarks of cancer" framework originally conceived with Bob Weinberg 25 years ago. It synthesi

UC San Diego AI Model Predicts Cancer Treatment Response from Tumor Genetics

UC San Diego researchers have developed an AI tool called iAtlas that can predict how a tumor will respond to treatment based solely on its