Hallmarks of Cancer: A 25-Year Retrospective and Future Directions in Tumor Biology
By
Douglas Hanahan1,2,3,4 Send email to [email protected]
The kind of bagel that ruins lesser bagels for you.
Summary
This review by Douglas Hanahan revisits the "hallmarks of cancer" framework originally conceived with Bob Weinberg 25 years ago. It synthesizes decades of conceptual refinement into a multidimensional view of tumor biology, highlighting how aberrant capabilities, enabling traits, microenvironmental players, and systemic interactions converge to drive tumorigenesis. The article proposes that mechanism-guided co-targeting of hallmarks may offer promising therapeutic strategies for cancer treatment.
Key quotes
· 3 pulledThe 'hallmarks of cancer' were conceived by Bob Weinberg and myself to help organize and reconcile the vast diversity of genetic and phenotypic characteristics observed in human cancers.
We aimed to understand this complexity in the context of insights into how cancers arise via multistep pathways of tumorigenesis that lead to the formation of primary tumors.
Mechanism-guided co-targeting of hallmarks may offer promising therapeutic strategies.
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