Yan Leyfman on CAR T-Cell Resistance and the Tumor Microenvironment

Dual tumour–myeloid targeting of glioblastoma with GPNMB CAR-T cells

AI-guided discovery identifies GPNMB as promising CAR T cell target for multiple cancers

Researchers developed an AI-driven framework for discovering CAR T cell therapy targets by integrating single-cell RNA sequencing data from

T cell-myeloid reprogramming overcomes immune resistance in colorectal cancer models

This article presents a scientific study on colorectal cancer (CRC) immunotherapy resistance. It shows that during anti-PD-1 treatment, tumo

BAFF CAR-T Cells (LMY-922) for Treatment of Refractory Hematologic Malignancies

Explainable machine learning-guided integrated multiomics analysis reveals macrophage-driven immune suppression in breast cancer

A Multicenter, Open-label, Non-randomized, Single-arm Phase 1/2 Study of Autologous Nano CD5-CAR T Cells for the Treatment of Relapsed/Refractory T-cell Acute Lymphoblastic Leukemia/Lymphoma