Drug-induced hypothermia shows therapeutic potential for acute ischemic stroke in animal models and early human trial
By
Di Wu
Summary
This article presents research on drug-induced hypothermia as a potential treatment for acute ischemic stroke. The study demonstrates that chlorpromazine combined with promethazine (C+P) successfully induced hypothermia and showed therapeutic effects in both mouse and nonhuman primate models of ischemic stroke. A phase 1 dose-escalation trial in humans found that all tested doses of C+P were well tolerated, with the highest dose suppressing plasma proteomic markers of systemic aerobic metabolism. The findings support further investigation into this therapeutic approach for stroke treatment.
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Twitter / XDrug-induced hypothermia shows therapeutic potential for acute ischemic stroke in animal models and early human trialscim.agKey quotes
· 5 pulledDrug-induced hypothermia can protect the mouse brain against hypoxic injury
chlorpromazine combined with promethazine (C+P) induced hypothermia and had therapeutic effects in a mouse model and a nonhuman primate model of ischemic stroke
all used doses of C+P were well tolerated and the highest dose suppressed plasma proteomic markers of systemic aerobic metabolism
These findings support further
Induction of a hypothermic and hypometabolic state is considered an avenue to treat...
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