Anti-aging drug combo dasatinib+quercetin causes brain damage in mice, study finds
Crusty in the right places. Worth the chew.
Summary
A study from the University of Connecticut published in PNAS found that the dasatinib+quercetin (D+Q) drug combination, widely studied for anti-aging, caused significant brain damage in mice by damaging myelin—the protective coating around nerve fibers. The damage resembled patterns seen in multiple sclerosis and "chemo brain," raising concerns about off-label anti-aging use of the drug combo. Surprisingly, the damaged cells gave scientists new insights into potentially understanding and repairing multiple sclerosis.
Key quotes
· 3 pulledWhen you administer this cocktail to an animal, young or old, the myelin damage is significant.
The damaged cells resembled those seen in multiple sclerosis, giving scientists a new lead in understanding—and potentially repairing—the disease.
The findings raise concerns about the growing use of D+Q in longevity research and off-label anti-aging therapies.
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