The antiphage mechanism of a widespread trypsin–MBL defense module
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bskyThe antiphage mechanism of a widespread trypsin–MBL defense moduledoi.orgProtease-triggered immunity shines in trypsin-MBL modules, key in bacterial defenses like Hachiman and Argonaute. ATP halts trypsin•HamAB; MBL's autodnase stays blocked. PMID:42243536, Nat Chem Biol 2026, @nchembio #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
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Congratulations to the Michelle Chang Lab, publishing “Targeted enzyme discovery using metal-coordination mining” today in @Nature. Great work from Yanni and Michelle. Full paper
nature.com
Congratulations to the Michelle Chang Lab, publishing “Targeted enzyme discovery using metal-coordination mining” today in @Nature. Great work from Yanni and Michelle. Full paper
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