Systematic discovery of motif-based interactions of the auxiliary domains of USP family deubiquitinases

Computational Design of Peptide Masks Enables Conditionally Active Miniprotein Therapeutics

This article presents a novel computational approach for designing conditionally active miniprotein binders through de novo peptide masks. T

Nature research paper: Alternate RNA decoding results in stable and abundant proteins in mammals

Analyzing Redundancy in Natural Protein Fold Space and the Role of Generative AI in Biomolecular Modeling

This research note from Ligo explores the concept of redundancy in natural protein fold space, examining how deep neural networks and genera

Nature research paper: Zero-shot design of drug-binding proteins via neural iterative selection−expansion

Nature research paper: Zero-shot design of drug-binding proteins via neural iterative selection−expansion

Biohub Platform: ESM Protein Models, Atlas, and API for Biomolecular Research

This article presents the Biohub Platform, which offers a suite of tools built on the ESM family of protein language models. It highlights t

Zero-shot design of drug-binding proteins via neural iterative selection−expansion