PCOS reframed as PMOS: A systemic endocrine and metabolic disorder requiring whole-body care

Summary

A new review proposes reframing PCOS (Polycystic Ovary Syndrome) as PMOS (Polycystic Ovary Syndrome with Metabolic and Endocrine Dysfunction), recasting it from a primarily fertility-focused disorder to a systemic whole-body endocrine and metabolic condition. The article explores how this reframing opens doors to earlier diagnosis, better risk profiling, and more individualized care. It details the complex pathophysiology involving feedback loops between the pituitary, liver, pancreas, and ovaries that create a hyperandrogenic state. The piece also highlights how inconsistent diagnosis and symptom-focused care have limited progress, while emerging tools like targeted therapies, biomarkers, machine learning, and organ-on-chip models may support more personalized treatment approaches.

Source

Twitter / XPCOS reframed as PMOS: A systemic endocrine and metabolic disorder requiring whole-body carenews-medical.net