Ovarian aging as a systemic regulator of female healthspan: A call for paradigm shift in geroscience

Summary

This Perspective article argues that the ovary should be recognized not merely as a reproductive organ but as a systemic regulator of female health and aging. It contends that ovarian aging is a primary determinant of healthspan and belongs at the center of geroscience research. The author calls for a paradigm shift in how scientists and clinicians view the ovary, emphasizing its role in regulating multiple physiological systems beyond reproduction, and highlighting the need for more research into ovarian aging as a key factor in female healthspan.