Membrane-Associated Biomolecules Enable Synthetic Cell Signaling: A Comprehensive Review
By
Chelsea Dack
Summary
This review article examines the role of membrane-associated biomolecules—including proteins, nucleic acids, and synthetic analogues—in enabling communication and signaling in bottom-up synthetic cells. It covers how these membrane-bound compartments (such as lipid vesicles, polymersomes, and proteinosomes) are engineered to mimic natural cellular signaling pathways, with applications in biosensing, therapeutics, and tissue engineering. The article provides a comprehensive overview of reconstituting native cellular machinery and designing synthetic alternatives for cell-cell communication.
Source
bskyMembrane-Associated Biomolecules Enable Synthetic Cell Signaling: A Comprehensive Reviewchemistry-europe.onlinelibrary.wiley.comKey quotes
· 3 pulledBottom-up synthetic cells are biomimetic compartments designed to reproduce selected features of living systems.
Membrane architectures include polymersomes, proteinosomes, and most commonly small, large, or giant unilamellar lipid vesicles (SUVs/LUVs/GUVs, 20 nm to 100 µm), which closely resemble natural membranes.
Membrane-associated proteins and nucleic acids are transforming synthetic cell communication, unlocking applications in biosensing, therapeutics, and tissue engineering.
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