Liver fat steers the outcome of advanced colorectal cancer
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Nature CommunicationsLiver fat steers the outcome of advanced colorectal cancernature.comNature, Published online: 01 July 2026; doi:10.1038/d41586-026-01747-7 In about 50% of people with colorectal cancer, tumour cells spread to distant organs. The ability of these metastases to grow into the liver tissue shapes prognosis. It emerges that liver fat promotes a form of liver metastasis with a poor prognosis, suggesting that individual-specific traits can inform risk stratification and treatment.
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