Surgical and Endoscopic Treatment Options for Gastroesophageal Reflux Disease

This JAMA Insights article reviews surgical and endoscopic treatment options for patients with gastroesophageal reflux disease (GERD) who do not respond adequately to behavioral modifications and medication. It covers various interventional approaches including radiofrequency therapy, plication techniques, and mucosal resection and ablation, providing clinical guidance on when these procedures are appropriate for GERD management.

;7d ago7 min readenInsight

science health medical procedures gastroenterology

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Key quotes

Gastroesophageal reflux disease (GERD) affects quality of life and may cause erosive esophagitis, Barrett esophagus, and esophageal strictures and adenocarcinoma.

The American Society for Gastrointestinal Endoscopy (ASGE) recommends initial management with behavioral modifications prior to or combined with medications, such as proton pump inhibitors (PPIs), histamine-2 receptor antagonists, or potassium-competitive acid blockers.

However, up to 54.1% of patients have persistent symptoms despite medical therapy.

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