Selective ROCK2 inhibitor TDI01 shows anti-fibrotic potential in liver fibrosis preclinical and clinical studies
By
Cheng Yi1 Send email to [email protected]
Summary
This article presents research on liver fibrosis, identifying that upregulation of ROCK2 in liver endothelial cells and perivascular hepatic stellate cells causes vascular niche dysfunction and triggers pro-fibrotic angiocrine signaling. The researchers developed a selective ROCK2 inhibitor (TDI01) that shows anti-fibrotic potency in preclinical MASH models and clinical trials in human patients with liver fibrosis.
Source
bskySelective ROCK2 inhibitor TDI01 shows anti-fibrotic potential in liver fibrosis preclinical and clinical studiescell.comKey quotes
· 3 pulledLiver fibrosis is a prominent pathological process contributing to death from hepatic diseases, including metabolic dysfunction-associated steatohepatitis (MASH).
We find that upregulation of Rho-associated coiled-coil containing kinase 2 (ROCK2) in liver endothelial cells (ECs) and perivascular hepatic stellate cells (HSCs) causes vascular niche dysfunction and triggers pro-fibrotic angiocrine signaling.
Targeting pro-fibrotic vascular ROCK2 by its selective inhibitor TDI01 exhibits anti-fibrotic potency in preclinical MASH models and clinical trials of human patients with liver fibrosis.
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