Metabolically engineered probiotic nanovaccine shows sequential immunomodulation for chronic MRSA bone infection treatment
This article presents research on developing a metabolically engineered nanovaccine using Lactococcus lactis outer membrane vesicles (Lac-OMVs) for treating chronic, drug-resistant bone infections caused by MRSA. The researchers screened Lac-OMVs and developed NAD+-Lac-OMV nanovaccines that sequentially modulate the immune system — first activating dendritic cells to fight infection, then reprogramming inflammatory macrophages to promote anti-inflammation and bone repair. The approach addresses the challenge of an immunosuppressive niche that enables persistent infection and impaired bone healing in chronic osteomyelitis.
Key quotes
Chronic, drug-resistant bone infection caused by methicillin-resistant Staphylococcus aureus (MRSA) features an immunosuppressive niche enabling persistent infection and impaired bone healing.
A specific treatment requires initial antibacterial immune activation against infection, followed by reshaping an anti-inflammatory microenvironment for later bone repair.
Lei et al. screen Lactococcus lactis OMVs (Lac-OMVs) and develop a metabolically engineered NAD+-Lac-OMV nanovaccine with potent tissue-repair therapeutic effects.
NAD+-Lac-OMVs sequentially activate dendritic cells by membrane components and reprogram inflammatory macrophages for anti-inflammation and bone repair by interior nicotinamide metabolites.
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