Fungal metabolite IM502 reprograms tumor-associated macrophages to enhance anti-cancer immunity
By
Yan Li4 Send email to [email protected]
Summary
Researchers developed an exogenous precursor-assisted fungal metabolite (ePAFM) strategy to generate bioactive fungal metabolites, identifying IM502—a meroterpenoid-like compound—as a potent modulator of tumor-associated macrophages (TAMs). IM502 works by inhibiting PI3Kγ and redirecting STAT signaling from STAT3/6 to STAT1/2 dominance, reversing TAM-mediated immunosuppression. This reprogramming of macrophages potently activates anti-tumor immunity, suppresses cancer growth and metastasis, and overcomes resistance to checkpoint blockade immunotherapy, revealing a promising new approach for cancer treatment.
Source
bskyFungal metabolite IM502 reprograms tumor-associated macrophages to enhance anti-cancer immunitycell.comKey quotes
· 3 pulledHu et al. discover a fungal metabolite, IM502, that re-educates immunosuppressive cells inside tumors.
By reprogramming macrophages, IM502 potently activates anti-tumor immunity, suppresses cancer growth and metastasis, and overcomes resistance to checkpoint blockade.
IM502 primarily inhibits PI3Kγ and redirects STAT signaling from STAT3/6 to STAT1/2 dominance, thereby reversing TAM-mediated immunosuppression.
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