PEP-EDIT: A Web Server for 3D Generation and Interactive Editing of Complex Peptide Structures
By
Chevrollier, Nicolas, Dougha, Alexis, Ye, Celine, Stratmann, Dirk, Moroy, Gautier, Rey, Julien, Murail, Samuel, Tufféry, Pierre
Summary
This article presents PEP-EDIT, a web server tool designed for generating and interactively editing 3D structures of complex peptides. It addresses the growing need in peptide drug development for accessible tools that can handle non-standard amino acids, non-amino components, multicyclic structures, branching, and other complex topologies. The tool enables researchers to generate and modify 1D, 2D, and 3D representations of complex peptides as a starting point for further optimization in drug discovery.
Source
bskyPEP-EDIT: A Web Server for 3D Generation and Interactive Editing of Complex Peptide Structuresdoi.orgKey quotes
· 4 pulledIn recent years, the development of peptide drugs has seen significant growth.
These molecules often go beyond simple linear chains composed of the standard 20 amino acids.
Peptide drugs frequently incorporate non-standard amino acids, non-amino components, and can exhibit mono- or multicyclic structures, branching, and other complex topologies.
Consequently, there is a growing need for accessible tools that allow researchers to easily generate and modify 1D, 2D, and 3D representations of these complex peptides.
You might also wanna read
Nature research paper: Zero-shot design of drug-binding proteins via neural iterative selection−expansion
Nature research paper: Zero-shot design of drug-binding proteins via neural iterative selection−expansion
Computational Design of Peptide Masks Enables Conditionally Active Miniprotein Therapeutics
This article presents a novel computational approach for designing conditionally active miniprotein binders through de novo peptide masks. T
pubs.acs.org·2d ago
Zero-shot design of drug-binding proteins via neural iterative selection−expansion
PEP: Specialized Compression Format for Pixel Art with Superior Size Reduction
PEP (Prediction-Encoded Pixels) is a specialized image compression format designed specifically for low-color pixel art (up to 256 colors).
github.com·10mo ago
OpenAI and Molecule.one demonstrate GPT-5.4-powered AI chemist improving medicinal chemistry reactions
OpenAI and Molecule.one demonstrate a near-autonomous AI chemist using GPT-5.4 that successfully improved a challenging reaction in medicina
openai.com·12d ago
GitHub Repository: 300-Line Implementation of Computational Life Research on Self-Replicating Programs
This article describes a GitHub repository containing a 300-line code reproduction of computational life research, where self-replicating pr
github.com·3mo ago
Comments
Sign in to join the conversation.
No comments yet. Be the first.