RegRegSEA: A web server for regulatory region set enrichment analysis in epigenomics
By
Wolff, Tobias, Grandke, Friederike, Sayeeda, Misbah, Hirsch, Pascal, Flotho, Matthias, Keller, Andreas
Summary
RegRegSEA is a web server tool designed for regulatory region set enrichment analysis of epigenomic data. It addresses the challenge of interpreting genome-wide epigenomic experiments like DNA methylation profiling and chromatin accessibility assays by identifying regulatory programs underlying coordinated changes across genomic regions. The tool overcomes limitations of existing approaches that either apply hard significance cutoffs (discarding moderate but biologically meaningful signals) or rely on gene-centric annotations that neglect enhancers and intergenic space.
Source
bskyRegRegSEA: A web server for regulatory region set enrichment analysis in epigenomicsdoi.orgKey quotes
· 3 pulledInterpreting genome-wide epigenomic experiments, such as DNA methylation profiling and chromatin accessibility assays, requires tools that can identify which regulatory programs underlie coordinated changes across genomic regions.
Without this regulatory context, lists of differential regions remain largely descriptive and difficult to interpret mechanistically.
Existing approaches either apply hard significance cutoffs that discard moderate but biologically meaningful signals, or rely on gene-centric annotations that neglect enhancers and intergenic space.
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