SPSignal: A structure-assisted web tool for predicting nuclear localization and export signals in proteins

Structural Systems Biology Toolkit (SSBtoolkit): From Molecular Structure to Subcellular Signaling Pathways

Lenacapavir-induced lattice hyperstabilization is central to HIV-1 capsid failure at the nuclear pore complex and in the cytoplasm

Lenacapavir (LEN) is the first human immunodeficiency virus type 1 (HIV-1) capsid inhibitor approved for clinical use in humans. It inhibits

Systematic characterisation of site-specific proline hydroxylation using hydrophilic interaction chromatography and mass spectrometry

We have developed a robust workflow to identify proline hydroxylation sites in proteins, combining hydrophilic interaction chromatography (H

Cholesterol-responsive NFE2L1-INSIG1 interaction controls VLDL secretion and metabolic dysfunction–associated steatohepatitis pathogenesis in mice

Cholesterol overload contributes to metabolic dysfunction–associated steatohepatitis (MASH) progression. One major pathway that limits hepat

The splice of life: an isoform-centric view of disease, technology, and therapeutics

Alternative splicing is a pervasive mechanism that expands the coding potential and functional complexity of the human genome. Dysregulated

Los investigadores descubren una nueva función de las proteínas mutadas en algunos de los cánceres más mortales

En un nuevo estudio a cargo de investigadores del Instituto Nacional del Cáncer (NCI), se demostró que las proteínas RAS mutadas ayudan a li