Vitamins A and D improve lung function in asthma through epigenetic regulation, study finds
By
Sze Man Tse Geneviève Mailhot
Summary
This scientific study investigates the impact of vitamins A and D on lung function, epigenetic ageing, and regulatory epigenetics in both children and adults with asthma. Using two large cohorts (1,165 children from Costa Rica and 1,041 adults), researchers measured serum miRNA profiles, blood DNA methylation, and vitamin levels. Key findings show that higher vitamin A in children was associated with better lung function (higher FEV1 and FVC), while vitamin D showed no association in children. In adults, both vitamins were positively associated with lung function, and vitamin D sufficiency corresponded to lower epigenetic ageing. The study identified that higher vitamin levels were associated with IRF5 regulatory cytosine hypomethylation, and mediation analyses indicated that DNA methylation and miRNAs partially mediate the relationship between vitamins and lung function outcomes.
Source
Twitter / XVitamins A and D improve lung function in asthma through epigenetic regulation, study findsthorax.bmj.comKey quotes
· 5 pulledIn children, higher vitamin A was associated with higher FEV1 (β=2.5, p=4.9 × 10-3) and FVC (β=7.6, p=7.7 × 10-14) but lower FEV1/FVC (β=−3.9, p=2.0 × 10-16); vitamin D showed no association.
In adults, both vitamins were positively associated with FEV1 (vitamin A: β=4.7, p=9.3 × 10-3, vitamin D: β=0.16, p=8.6 × 10-3) and FVC (vitamin A: β=3.4, p=3.0 × 10-2, vitamin D: β=0.18, p=4.6 × 10-4); only vitamin A was associated with FEV1/FVC.
Vitamin D sufficiency corresponded to lower epigenetic ageing in adults.
Higher vitamin levels were associated with IRF5 regulatory cytosine hypomethylation at cytosine-guanine dinucleotides (CpG), corresponding to better lung function and lower ageing.
Vitamin A, but not vitamin D, in children was associated with better lung function and lower epigenetic ageing in asthma, with effects mediated by DNA methylation and miRNA regulation.
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