Study Finds Link Between Farming Exposure and ALS Mortality Risk in Postmenopausal Women
By
Talbott, Evelyn O., Malek, Angela M., Song, Ruopu, Whitsel, Eric A., Meliker, Jaymie R., Arena, Vincent C.
Summary
This study, nested within the Women's Health Initiative, examined the association between farming/insecticide exposure and ALS mortality risk among 93,676 postmenopausal women over 25+ years. Results showed that women with farming exposure had significantly higher odds of ALS death (aOR = 1.59), with risk increasing with longer exposure duration (≥20 years: aOR = 2.32). The risk was highest among women who both had farming exposure and smoked (aOR = 2.10). Little evidence was found for insecticide exposure alone, though statistical power was limited.
Source
Key quotes
· 5 pulledAmong post-menopausal women with 25+ years follow-up, a significant association was noted between farming exposure and risk of ALS death.
This increased risk was highest among those who ever smoked.
Future studies should include biomarkers of exposure and large cohorts of men and women with occupational and residential histories.
Cases had higher odds of farming exposure than controls (adjusted odds ratio [aOR] = 1.59, 95% CI: 1.09–2.31)
Women with farming and smoking exposure had higher odds of ALS death (aOR = 2.10, 95% CI: 1.26–3.51, p = 0.0045)
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