Occupational standing, walking, and forward bending during pregnancy linked to increased miscarriage risk in Danish nationwide study
Summary
This nationwide Danish register-based cohort study (2004-2018) examined 803,829 pregnancies among 475,312 women to investigate the association between occupational physical exposures (standing, walking, and forward bending ≥30°) during pregnancy and miscarriage risk. Using a quantitative, pregnancy-specific job exposure matrix linked to occupational codes, researchers found that all three exposures were associated with increased hazards for miscarriage. The adjusted hazard ratios per additional hour were: 1.03 (standing), 1.18 (walking), and 1.36 (forward bending). The association was stronger among women with absence from work the preceding week. Forward bending showed a consistent exposure-response relationship, while standing and walking associations decreased at the highest exposure quartile. The authors call for replication in comparable populations with additional health information.
Source
Twitter / XOccupational standing, walking, and forward bending during pregnancy linked to increased miscarriage risk in Danish nationwide studyoem.bmj.comKey quotes
· 5 pulledAll three exposures were associated with increased hazards for miscarriage.
The aHR for miscarriage was 1.03 (95% CI: 1.02 to 1.04) per additional hour of occupational standing, 1.18 (95% CI: 1.15 to 1.22) per additional hour of occupational walking and 1.36 (95% CI: 1.30 to 1.41) per additional hour of occupational forward bending.
The aHR was more pronounced among women with absence from work the preceding week than among those without.
Post hoc quartile analyses indicated a consistent exposure–response relationship for forward bending, while the associations for standing and walking decreased at the highest quartile.
Replication in comparable populations incorporating smoking status and other health information is needed to validate these associations.
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