Development of LRRC15-binding disulfide-constrained peptides for PET imaging of cancer-associated fibroblasts

Antibody-ligand motif optimization enables multitarget switchable CAR-T therapy against solid tumors

This article presents a research study on optimizing a multitarget switchable CAR-T (sCAR-T) strategy to overcome antigenic heterogeneity an

AI-guided discovery identifies GPNMB as promising CAR T cell target for multiple cancers

Researchers developed an AI-driven framework for discovering CAR T cell therapy targets by integrating single-cell RNA sequencing data from

Clinical Study of 177Lu-JH040182 in Patients With FAP-Positive Malignancies

Computational Design of Peptide Masks Enables Conditionally Active Miniprotein Therapeutics

This article presents a novel computational approach for designing conditionally active miniprotein binders through de novo peptide masks. T

AI-Driven Protein Binder Design: Progress and Pitfalls in Evaluation Practices

This article discusses the rapid advancement of de novo protein binder design using AI, including antibodies and nanobodies. While the field

A Study Comparing BL-M07D1 With DS-8201 in Patients With HR-Positive, HER2-Low Expressing Recurrent/Metastatic Breast Cancer