Anti-PCSK9 Antibody Tafolecimab and Anti-PD-1 Antibody Sintilimab Combined With Neoadjuvant Chemoradiotherapy for pMMR/ MSS Locally Advanced Rectal Cancer : A Prospective, Multicenter, Randomized, Open-Label, Parallel-Controlled Trial
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Conditions : Local Advanced Rectal Cancer; PD-1 Inhibitor; PCSK9 Inhibitor; RCT; Radiotherapy; Capecitabine; Oxaliplatin Interventions : Radiation: Short-course radiotherapy; Drug: CAPOX (oxaliplatin/capecitabine); Drug: Sintilimab; Drug: Tafolecimab Sponsors : Guangdong Provincial People's Hospital; Beijing Friendship Hospital; Cancer Institute and Hospital, Chinese Academy of Medical Sciences; Fudan University; Sixth Affiliated Hospital, Sun Yat-sen University; Sun Yat-Sen University Cancer Center; Union Hospital, Tongji Medical College, Huazhong University of Science and Technology; Affiliated Hospital of Qinghai University; Zhangzhou Hospital, Fujian Province; The First Affiliated Hospital of Xiamen University; Ruijin Hospital; The First Hospital of Jilin University; Peking University Cancer Hospital & Institute; Nanchang University Second Affiliated Hospital; The First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine; Third Affiliated Hospital, Sun Yat-Sen University; Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University; Meizhou People's Hospital Not yet recruiting
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