AI-Powered Discovery Identifies Antimicrobial Peptides from Prion Proteins
By
Sophia Ktori
Summary
Researchers at the University of Pennsylvania used a deep learning platform called APEX 1.1 to scan millions of short protein fragments from nearly 3,000 prion and prion-like proteins. They identified over a thousand candidate antimicrobial peptides, including one called "Prionin," which showed effectiveness against drug-resistant bacterial strains. This discovery is unexpected because prions are typically associated with neurodegenerative diseases, not immunity or antibiotic discovery.
Source
bskyAI-Powered Discovery Identifies Antimicrobial Peptides from Prion Proteinsgenengnews.comKey quotes
· 3 pulledThe Penn scientists used a deep learning platform called APEX 1.1 to scan millions of short protein fragments derived from nearly 3,000 prion and prion-like proteins.
The search identified more than a thousand candidate antimicrobial peptides.
Researchers say the discovery is unexpected because prions are usually discussed in the context of misfolding, aggregation, and brain disease—not immunity or antibiotic discovery.
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