UVM study finds H1N1 and H3N2 flu viruses use different cellular entry routes, challenging long-held assumptions
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ByDavid MurcianoEarth.com staff writer
Summary
Researchers at the University of Vermont's Larner College of Medicine have discovered that H1N1 and H3N2 influenza A strains use different cellular entry routes to infect lung tissue, overturning the long-held assumption that all flu viruses break into cells the same way. The study, published in The Journal of Virology, found that each strain relies on distinct proteins for cellular entry, meaning blocking the right protein could lock out a specific virus. This breakthrough could fundamentally reshape how antiviral drugs are designed and potentially lead to a universal flu cure.
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bskyUVM study finds H1N1 and H3N2 flu viruses use different cellular entry routes, challenging long-held assumptionsearth.comKey quotes
· 3 pulledA team at the Larner College of Medicine at the University of Vermont has stumbled onto a finding that upends a long-standing assumption about influenza: not all flu viruses break into human cells the same way.
The discovery, published in The Journal of Virology, shows that H1N1 and H3N2, the two most common strains of influenza A, rely on distinct cellular routes to infect lung tissue, a distinction that could reshape how antiviral drugs are designed.
The researchers identified that the viruses depend on different proteins to gain entry. Strip the right one, and a specific virus is locked out.
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