Nanoliposome-based subunit vaccine platform targets multiple respiratory viruses simultaneously
By
Jonathan F. Lovell
Summary
This article describes a novel nanoliposome-based subunit vaccine platform designed to simultaneously target multiple respiratory viruses, including seasonal influenza strains, SARS-CoV-2, and respiratory syncytial virus (RSV). The platform codisplays recombinant hemagglutinin ectodomains from three influenza strains and the SARS-CoV-2 receptor binding domain, offering a promising approach for multi-pathogen vaccination in a single shot.
Source
bskyNanoliposome-based subunit vaccine platform targets multiple respiratory viruses simultaneouslyscience.orgKey quotes
· 3 pulledSeasonal influenza viruses, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and respiratory syncytial virus (RSV) drive substantial mortality worldwide.
Vaccines against these respiratory viruses are traditionally administered separately, and, while some emerging technologies have shown promise to address multiple pathogens simultaneously, subunit protein vaccines have lagged behind.
Here, we describe a nanoliposome-based vaccine platform that codisplays recombinant hemagglutinin ectodomains from three seasonal influenza strains, the SARS-CoV-2 receptor binding domain
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