Madelyn J. Blake, Sally E. Prins, Jeffrey Blake, Lynn M. Hartweck, Jenna B. Mendelson, Steeve Provencher, Sandra Breuils-Bonnet, Sebastien Bonnet, Kurt W. Prins

Pulmonary arterial hypertension induces a metabolic and inflammatory hepatopathy

BACKGROUND Right ventricular failure (RVF) is a major determinant of mortality in pulmonary arterial hypertension (PAH), and hepatic dysfunction predicts adverse outcomes. However, the cell-specific effects of PAH/RVF on the human liver remain poorly defined.METHODS We performed single-nucleus RNA-seq (snRNA-seq) of autopsy-derived liver tissue from 5 patien