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Use of circulating tumour DNA to prospectively guide a switch from targeted to immune therapy in BRAF mutant advanced melanoma: the randomised phase II CAcTUS trial

7d ago· 1 min readNews

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bskyUse of circulating tumour DNA to prospectively guide a switch from targeted to immune therapy in BRAF mutant advanced melanoma: the randomised phase II CAcTUS trialdoi.org
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Exploring 21 patients with BRAF mutant melanoma, the CAcTUS trial tests therapy switch: TT or CPI, then alternative at progression; potential improved long-term survival. PMID:42168180, Nat Commun 2026, @NatureComms #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

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