All Topics
All Topics
Technology
Technology
AI
AI
Business
Business
Entertainment
Entertainment
News
News
Programming
Programming
Science
Science
Design
Design
Environment
Environment
Finance
Finance
Crypto
Crypto
Politics
Politics
Sports
Sports
Education
Education
Gaming
Gaming
Art
Art
Music
Music
Health
Health
Security
Security
Books
Books
Food
Food
Travel
Travel
Personal
Personal
Bluesky
Twitter

The targeted cytosolic degradation of class I histone deacetylases is essential for efficient alphaherpesvirus replication

Viral infection triggers a robust DNA damage response (DDR), reshaping the host chromatin landscape to facilitate viral replication. Here, we uncover a novel mechanism by which alphaherpesviruses…

Read the full article

You might also wanna read

Identification of a mechanism-based binding mode for a histone deacetylase 6 inhibitor

Breaking: BAS-2, a new HDAC6 inhibitor without typical zinc-binding group was identified! Using X-ray, mutagenesis, SARs & modeling, its uni

doi.org·2d ago

DDX6 helicase suppresses innate immune responses by disrupting endogenous double-stranded RNA stability in cancer cells

Cellular double-stranded RNA (dsRNA) can activate immune pathways similar to viral RNA. Adenosine deaminases acting on RNA 1 (ADAR1)–mediate

scim.ag·22d ago

Therapeutic inhibition of telomeric DNA damage response rescues hematopoietic dysfunction driven by telomere shortening and aging

Therapeutic inhibition of telomeric DNA damage response rescues hematopoietic dysfunction driven by telomere shortening and aging

nature.com·10d ago

αKG-mediated carnitine synthesis drives DNA repair via histone acetylation | Nature

αKG depletion sensitizes HR-proficient cells to DNA-damaging agents via metabolic regulation o… PMID:42203879, Nature 2026, @Nature @OTSocie

doi.org·1mo ago

DNA-PK-mediated CRTC2 phosphorylation promotes NHEJ and suppresses antitumor immunity via relocation to repair complexes

CRTC2 shifts roles from transcription to DNA repair, enhancing NHEJ and suppressing antitumor immunity. Study reveals its critical involveme

doi.org·20d ago

Nature research paper: Replication-stress-induced chromatin loops protect fork stability

Nature research paper: Replication-stress-induced chromatin loops protect fork stability

go.nature.com·4d ago

Comments

Sign in to join the conversation.

No comments yet. Be the first.