The DBD-α4 helix of EWSR1::FLI1 is required for GGAA microsatellite binding that underlies genome regulation in Ewing sarcoma
Ewing sarcoma is the second most common bone cancer in children and young adults. In 85% of patients, a translocation between chromosomes 11 and 22 results in a potent fusion oncoprotein…
Read the full articleYou might also wanna read
D&D-seq: A single-cell immuno-tethering method for mapping weak DNA-protein interactions
D&D-seq, a single-cell immune-tethering strategy, captures weak and transient DNA-protein interactions to enable integrated, genome-wide ana
Fusion-positive rhabdomyosarcoma oncofusions share a common interactome
Scientists reveal FP-RMS oncofusions, 7 types, share a PAX3/7 DNA-binding domain, a common protein network, bind overlapping genes, and driv
Nature research paper: Replication-stress-induced chromatin loops protect fork stability
Nature research paper: Replication-stress-induced chromatin loops protect fork stability
ZNF274 constrains lineage plasticity and drives intrinsic resistance to CDK7 inhibitors in pancreatic cancer
ZNF274 limits pancreatic cancer plasticity by maintaining chromatin and suppressing genes. Loss of ZNF274 shifts from classical to invasive
Study Reveals How Extrachromosomal DNA Drives Oncogene Evolution in Glioblastoma Tumors
AbstractOncogenes amplified on extrachromosomal DNA (ecDNA) contribute to treatment resistance and poor survival across cancers. Currently,
aacrjournals.org·9mo ago
Taking apart the DNA-methylation clock with an epigenetic progeria syndrome
Taking apart the DNA-methylation clock with an epigenetic progeria syndrome
Comments
Sign in to join the conversation.
No comments yet. Be the first.