Targeting RBM5 may help disrupt 'undruggable' MYC in childhood leukemia
Scientists from St. Jude Children's Research Hospital and collaborators have identified the RNA-binding protein RBM5 as a potential vulnerability in a set of difficult-to-treat childhood leukemias…
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Key PointsMYB binding is sufficient to generate enhancers de novo, including the formation of enhancer-promoter contacts.MYB loss in acute l
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