Study finds persistently high mortality in drug-resistant Gram-negative infections despite new antibiotics

Summary

This retrospective cohort study examines whether mortality rates among patients with difficult-to-treat resistant (DTR) Gram-negative infections have changed since the introduction of newer, next-generation antibiotics in the USA. Despite the availability of these improved antibiotics, the study finds that mortality and the use of in-vitro discordant initial antibiotics remain unacceptably high. The research highlights that prompt recognition of both the pathogen and resistance phenotype is crucial for reducing mortality. A notable decrease in adjusted mortality over time was observed for Pseudomonas aeruginosa bloodstream infections, though this finding is considered hypothesis-generating due to the small cohort size.

Source

B

bskyStudy finds persistently high mortality in drug-resistant Gram-negative infections despite new antibioticsthelancet.com