Single DNA injection shows long-lasting weight loss and glucose control in mouse study
Scientists at The Wistar Institute have demonstrated that a single injection of a circular DNA molecule (a plasmid) can produce weight loss and blood glucose control in mice lasting up to 10 times longer than current GLP-1 drugs like Ozempic and Wegovy. The approach uses a novel delivery method that could eliminate the need for frequent dosing, potentially improving patient access and adherence if successful in human clinical trials.
Key quotes
If shown to be successful in clinical trials, this new method of delivery could eliminate the need for repeated dosing, which currently limits patient access and adherence to these therapies.
A single injection of a small, circular piece of genetic instructions can produce weight loss and blood glucose control in murine models that lasts up to 10 times as long as incretin-mimicking drugs like Ozempic and Wegovy.
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