SARM1 inhibitors advance to clinical trials as potential treatment for ALS and neuropathy
By
Laurel Oldach
Summary
The article covers the entry of SARM1 inhibitors into clinical trials as a potential treatment for neurodegenerative diseases like ALS and peripheral neuropathy. SARM1 is a protein that acts as an executioner in the enzymatic signaling cascade that coordinates axon die-off in nerve cells. Researchers are exploring ways to block this NAD hydrolase to save axons from neurodegeneration, though safety concerns remain about how to effectively and safely inhibit this pathway.
Source
bskySARM1 inhibitors advance to clinical trials as potential treatment for ALS and neuropathycen.acs.orgKey quotes
· 3 pulledWhen the long cabling of nerve cells die off in neurodegenerative diseases, they don't just wither away passively. Instead, there's an enzymatic signaling cascade that coordinates axon die-off.
One key executioner is a protein called SARM1, which regulates this process.
Blocking the NAD hydrolase may save axons from neurodegeneration, if researchers can figure out a safe way to do it.
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