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Why promising animal study results often fail in human trials: the gap between mice and medicine

By

SMC Spain

10h ago· 17 min readenInsight

Summary

This article explains the gap between promising animal studies and actual human treatments in biomedicine. It uses the historical example of Judah Folkman's cancer research — which showed dramatic results in mice but failed in human trials — to illustrate why animal study results must be interpreted cautiously. The piece covers why mice are the most common lab animals, the lengthy process from animal testing to human treatments, the limitations of disease models, and how media and scientists should communicate findings without raising false hopes.

Key quotes

· 3 pulled
If you have cancer and you're a mouse, then we'll be able to take good care of you.
Far from the miracle cure, in clinical trials with patients, its effect was considerably less.
James Watson himself claimed in the New York Times that Folkman was 'going to cure cancer within two years'.
Snippet from the RSS feed
We often see headlines claiming that new research has found a ‘cure’ for diseases. However, what are the real chances of this being true? How does the current stage of the research affect its ultimate outcome? Has it already been tested on humans, or only

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