Oestrogen fluctuations during menstrual cycle may alter drug delivery to women's brains, study finds
By
Starre Vartan
Summary
Research into the experimental drug davunetide, initially abandoned after a failed late-stage trial, has revealed that fluctuating oestrogen levels during the menstrual cycle may influence how much of the drug reaches women's brains. This discovery suggests that the effectiveness of brain-targeting drugs could vary depending on hormonal levels, potentially explaining why some treatments appear ineffective in mixed-gender trials despite working in women. The findings open the door to more personalized, hormone-aware approaches to drug development and dosing.
Source
Twitter / XOestrogen fluctuations during menstrual cycle may alter drug delivery to women's brains, study findsnewscientist.comKey quotes
· 3 pulledFluctuating oestrogen levels may influence how much of the drug reaches the brain, raising the possibility that its effectiveness – and those of other treatments – varies depending on our levels of hormones.
The experimental drug davunetide was showing promise for degenerative brain conditions until, more than 10 years ago, a pivotal late-stage trial fell flat.
Upon closer inspection, scientists found the drug may actually be effective in women.
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